Medically reviewed by Uri Gedalia, MD, FACS
Chief Medical Officer, TrufaMED Urgent Care & Concierge Medicine
Board-Certified, General Surgery
Last reviewed: September 2026
The right time to run a comprehensive longevity workup is when you have a clean baseline. Late September through early November is the sweet spot for most Miami adults: summer training and travel are recent enough to inform results, holiday season has not yet introduced caloric and stress confounders, and you have time to act on findings before year-end.
This is the panel we run annually for our preventive care and concierge patients pursuing serious longevity goals.
The Core Panel
Cardiovascular risk
- Lipid panel: total cholesterol, LDL-C, HDL-C, triglycerides
- ApoB: the most informative single cardiovascular risk marker
- Lp(a): genetic risk factor, one-time test typically
- hsCRP: inflammation marker
- Homocysteine
- Optional: lipoprotein particle analysis (NMR) for advanced lipidology cases
Metabolic
- Fasting glucose
- HbA1c
- Fasting insulin (often more informative than HbA1c in pre-diabetic patients)
- Comprehensive metabolic panel: kidney function, liver function, electrolytes
- Uric acid
Hormones
- Total and free testosterone (men) or full female panel (estradiol, progesterone, FSH, LH, DHEA-S) with cycle context
- SHBG
- Full thyroid: TSH, free T4, free T3, reverse T3, anti-TPO, anti-TG
- Cortisol AM (fasted)
- IGF-1
- DHEA-S
- Prolactin
Vitamins and minerals
- Vitamin D 25-OH
- Vitamin B12, folate, methylmalonic acid
- Ferritin and iron panel
- Magnesium RBC
- Zinc
- Omega-3 index (optional)
Hematology and inflammation
- Complete blood count with differential
- Erythrocyte sedimentation rate
- Fibrinogen
Cancer screening (age-appropriate)
- PSA in men over 40 or with family history
- CA-125 in women based on individual risk
- Colonoscopy on appropriate cadence (typically every 10 years starting age 45)
- Mammography annually starting age 40
- Skin exam annually with dermatology
- Optional: multi-cancer early detection test (Galleri or equivalent) for high-risk patients
Imaging (selected)
- Coronary artery calcium score: one-time scan, valuable for patients without established cardiovascular risk
- DEXA scan: bone density, body composition; annually or every other year
- Full-body MRI: optional, for high-risk patients with longevity-focused screening goals
- Echocardiogram if clinically indicated
How We Run It
The workup is delivered as a two-visit sequence for most patients:
- Visit 1 (45 to 60 minutes): History review, goals discussion, physical examination, blood draw. We send out specialized tests with results returning in 7 to 14 days.
- Visit 2 (45 to 60 minutes): Results review, individualized recommendations, supplement protocol, any prescription medications, and follow-up cadence agreed.
Concierge members can do this in-clinic or as a home visit; preventive care patients typically do it in-clinic.
Acting On Findings
The panel is only as useful as the actions it informs. Common outcomes:
- Vitamin D repletion if 25-OH-D is below 40 ng/mL
- Iron repletion if ferritin is below 50 ng/mL (with consideration of why)
- Thyroid optimization if TSH and free T3 patterns suggest sub-clinical dysfunction
- Lipid management if ApoB is above target for individual risk
- Cardiac referral if coronary calcium score is elevated or new murmur on exam
- Hormone optimization where clinically indicated and patient interested
- Inflammation workup if hsCRP is persistently elevated
- Sleep evaluation if cortisol and metabolic patterns suggest disrupted sleep
Cost
Out-of-pocket: $700 to $1,800 depending on which add-ons are included. Significant portions are covered by insurance when clinically indicated. We provide itemized invoices for reimbursement.
Concierge membership often makes the annual workup more straightforward; some tier benefits include the panel as part of the membership.
Frequently Asked Questions
Should I fast for the blood draw?
Yes: 10 to 12 hour fast. Water is fine. We schedule morning blood draws.
How long do specialized results take?
Most standard results come back same-day to 24 hours. Specialty markers (ApoB, Lp(a), specialty hormones) take 5 to 14 days.
Do I need to repeat this every year?
Core metabolic, hormones, vitamins, and inflammation: annually. Cardiovascular calcium score: typically one-time or every 5 to 10 years. Cancer screening: per age-appropriate schedule.
Is this the same as the panels Peter Attia or Tim Ferriss use?
Conceptually similar with our individualization. See our specific posts on Peter Attia lab panel and Tim Ferriss longevity stack for context.