
A physician-ordered Natera blood test that reads the genes behind inherited cancer risk, so you can plan ahead.
Joint Commission AccreditedEmpower is a physician-ordered genetic test from Natera that analyzes the genes associated with inherited cancer syndromes. From a single blood or saliva sample, it looks for changes in genes such as BRCA1, BRCA2, and the Lynch syndrome genes. A positive result identifies an inherited mutation that raises lifetime risk for cancers including breast, ovarian, colorectal, uterine, pancreatic, prostate, gastric, and melanoma.
The purpose is to give your physician information early enough to act on. A result is reviewed with a board-certified TrufaMED doctor, and any plan is built around what the test actually finds, with proactive screening and prevention chosen together with you. About one in ten cancers is hereditary, and knowing your status can change how, and how often, you are watched.
Natera’s three-minute overview of how the hereditary cancer test works, from the sample to the results conversation.
Video by Natera, the laboratory that performs the Empower test.
Three of the genes Empower reads most often, compared with the general population. A carrier’s number is a range, and your physician reads it against your own history.
Source: NCCN Clinical Practice Guidelines in Oncology, Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic, v.3.2023, as summarized by Natera. Risk estimates for a positive result are typically based on people with a family or personal history of cancer. Your risk may differ.
Hereditary cancer testing is recommended far more often than it is ordered. These figures come from the published literature Natera cites for the Empower test.
Sources: Kurian et al., JAMA 2023 (germline testing after cancer diagnosis); Hampel and de la Chapelle, Familial Cancer 2013 (Lynch prevalence); National Cancer Institute Blue Ribbon Panel Report 2016; Knerr et al., Journal of the National Cancer Institute 2019; Domchek et al., JAMA 2010.
A pathogenic variant in any of the genes below raises lifetime risk for the matching cancer. Finding it earlier lets your physician build a surveillance plan, discuss risk-reducing options, and offer testing to relatives.
Hereditary breast and ovarian cancer syndrome, the most common reason for hereditary testing. Lifetime breast-cancer risk can reach 70 percent in BRCA1 carriers.
Lynch syndrome, the leading cause of inherited colorectal cancer. Carriers benefit from colonoscopy starting in their twenties and gynecologic surveillance.
Familial adenomatous polyposis, MUTYH-associated polyposis, Peutz-Jeghers, and juvenile polyposis syndrome, each driving very high colorectal and related risk.
Inherited pancreatic-cancer predisposition. A positive result can qualify carriers for dedicated pancreatic surveillance programs.
Familial melanoma and related skin-cancer risk. Carriers benefit from regular dermatologic screening and sun-protection counseling.
Li-Fraumeni (breast, sarcoma, brain, adrenal), Cowden / PTEN hamartoma (breast, thyroid, endometrial), and hereditary diffuse gastric and lobular breast cancer.
Natera offers Empower as a set of panels, from two genes to 85. Your physician selects the panel that fits your personal and family history, or builds a custom panel from more than 190 genes.
The two genes behind most hereditary breast and ovarian cancer. Often the right panel when a known family BRCA mutation is being confirmed.
Inherited colorectal and endometrial cancer risk. A positive result moves colonoscopy into the twenties and adds gynecologic surveillance.
Breast, ovarian, and endometrial cancer genes plus the Lynch genes. The panel most often ordered in women’s health and primary care.
The most commonly screened hereditary cancer genes across nine cancer types, including pancreatic, prostate, gastric, kidney, and melanoma.
Everything in Multi-Cancer plus genes with emerging evidence of elevated risk. The widest single panel Natera offers.
A rapid panel for patients facing surgical decisions after a breast cancer diagnosis, where the result can change the operation.
Gene counts follow Natera’s published panel lists as of September 2026. Every Empower order includes RNA analysis when a detected variant may affect gene splicing, with no extra sample. After a positive result, blood relatives can be tested on the same panel at no additional charge within 180 days of the original report.
A positive Empower result is information and not a diagnosis. Acted on early, it meaningfully lowers future cancer risk through four pathways your physician coordinates.
Earlier and more frequent imaging, such as annual breast MRI alternating with mammogram for BRCA carriers, or colonoscopy every one to two years from your twenties for Lynch carriers. The goal is catching anything at its most treatable stage.
Where appropriate and personally chosen, preventive medication or risk-reducing surgery can lower lifetime cancer risk substantially. These are discussed openly, never pushed, and always your decision.
First-degree relatives each have a 50 percent chance of carrying the same variant. Once it is identified in one person, focused single-site testing for parents, siblings, and children is simpler and far less costly.
Your physician follows National Comprehensive Cancer Network guidelines for hereditary cancer management, the same evidence-based protocols used at major academic cancer centers.
Meet a TrufaMED MD in person or by telehealth. We review your personal and family history, confirm clinical eligibility, and order the test.
A blood draw or saliva kit at our Surfside clinic. The sample ships to the Natera laboratory, which is CLIA-certified and CAP-accredited.
Next-generation sequencing of every gene on your panel, with RNA analysis added when a variant may affect splicing. Results typically return in about two weeks.
You review the signed report with your physician, who builds your surveillance and prevention plan and coordinates specialist referrals when indicated.
Certain personal and family patterns point to an inherited risk worth testing for. Your physician confirms eligibility, which also matters for insurance coverage.
Multiple relatives with breast, ovarian, colorectal, pancreatic, or prostate cancer, especially on the same side of the family.
A personal or family cancer diagnosis before age 50 is a strong indicator of an inherited cause.
Roughly 1 in 40 Ashkenazi Jewish individuals carries a BRCA1 or BRCA2 founder mutation.
Two or more separate primary cancers, or bilateral cancers such as both breasts or both kidneys.
A first- or second-degree relative has already tested positive for a cancer-predisposition gene.
Many guidelines recommend germline testing after breast, ovarian, pancreatic, colorectal, or prostate cancer, regardless of family history.
Screening is only as good as what happens after the result. At TrufaMED, every step is owned by a board-certified physician.
Every Empower test is ordered, interpreted, and acted on by a board-certified MD. You are never handed a raw report and left to figure it out alone.
Physician-ledTrufaMED is the only Joint Commission-accredited urgent care in Florida, one of just eight nationwide, the same accreditation hospitals carry.
AccreditedYour blood is drawn at our Surfside clinic by a licensed provider during the visit and ships to the Natera laboratory the same day.
Same-day shippingMost major plans cover Empower when NCCN criteria are met. Our team handles benefits verification and prior authorization before any sample is collected.
Benefits verifiedYou go over your report in person or by telehealth with your physician, with time to ask questions and decide on next steps.
In person or telehealthOn-site labs, digital X-ray, ultrasound, Galleri multi-cancer detection, and a full clinical team for whatever surveillance your plan calls for.
Full facilityNatera bills the Empower test to your insurance plan. Most major plans cover it when NCCN clinical criteria are met. These include a personal or family history of cancer, an ancestry-based risk, or a prior cancer diagnosis. Our team verifies your benefits and obtains prior authorization before any sample is collected. Prior authorization is not a guarantee of coverage. After the claim is processed, you may owe Natera a deductible or coinsurance. Your TrufaMED Genetic Screening Visit is $205, self-pay, and never billed to insurance. It covers your physician consult, in-clinic sample collection, and the results review. For general coverage questions, see our insurance information.
Self-pay is $450 for the Empower test, your physician consult, sample collection, and the results review. If your plan does not cover the test, this is the lower-cost path. Without coverage, Natera bills you its own cash price for the test, and the $205 visit is added to that. We confirm your expected total before any sample is collected. Payment plans are available. Call (305) 537-6396 with any question before you book.
Both options include the physician consult, test order, sample collection, and results review. The $450 option also includes Natera’s laboratory analysis. Looking at other genetic options? Compare Horizon carrier screening for family planning and Galleri multi-cancer early detection for screening across many cancers at once.
Every order, interpretation, and follow-up is delivered by a board-certified MD, with the clinical depth to turn a genetic result into a real plan.
Dr. Gedalia is a board-certified general surgeon and the Chief Medical Officer of TrufaMED. He oversees clinical protocols for hereditary cancer screening interpretation and the integration of genetic risk into surgical and surveillance decisions, drawing on a surgical background that helps translate a result into a concrete prevention plan.
Dr. Naidoo is a board-certified emergency-medicine physician and TrufaMED’s Medical Director. He leads day-to-day physician operations and results-review visits, and coordinates downstream specialist referrals when genetic screening identifies an elevated risk that calls for further workup.
What patients ask before ordering the Empower test at TrufaMED.
Most major plans cover Empower when NCCN criteria are met, such as a personal or family history of cancer. Natera bills the test to your plan after our team verifies benefits and obtains prior authorization. Prior authorization is not a guarantee of coverage. With insurance, you pay TrufaMED $205 for the Genetic Screening Visit, which we never bill to insurance. If your plan does not cover the test, the $450 all-in self-pay option is the lower-cost path. We confirm your expected total before any sample is collected.
A positive result indicates an elevated lifetime risk and does not mean a current cancer diagnosis. Your TrufaMED physician builds a personalized risk-management plan that may include enhanced imaging surveillance (such as breast MRI or transvaginal ultrasound), risk-reducing medication, surgical risk-reduction options, and coordinated referrals to oncology when indicated. We also help organize cascade testing for first-degree relatives, who each have a 50 percent chance of carrying the same variant.
Either, depending on the panel and your preference. Most adults at our Surfside clinic provide a blood sample drawn by a licensed provider during the visit. Saliva collection kits are available for select circumstances. Both methods analyze the same genes with the same accuracy.
Results typically return from the Natera laboratory in about two weeks from the date the sample is received. We schedule your results visit as soon as the signed report is available, and you review it in person or by telehealth with a board-certified physician.
Hereditary cancer screening is worth considering if you have a family history of breast, ovarian, colorectal, pancreatic, or prostate cancer, especially on the same side of the family; a personal or family cancer diagnosis before age 50; Ashkenazi Jewish ancestry (roughly 1 in 40 carry a BRCA founder mutation); two or more primary cancers or bilateral cancers; or a known cancer-predisposition gene in a close relative. Your physician confirms clinical eligibility during the consult.
A VUS is a genetic change whose clinical impact is not yet established. It is not treated as a positive result and does not change your clinical management. Variants are reclassified over time as more data accumulates, and we re-contact patients if a VUS is later reclassified.
Yes. Many guidelines recommend germline testing for any patient with a personal history of breast, ovarian, pancreatic, colorectal, or prostate cancer, regardless of family history or age at diagnosis. Results can inform treatment decisions, guide surveillance for second cancers, and open the door to cascade testing for relatives.
The difference is substantial. Direct-to-consumer ancestry tests typically genotype only a handful of common variants and can miss the large majority of clinically actionable mutations. Empower sequences every gene on the panel with next-generation sequencing, adds RNA analysis when a variant may affect splicing, and reports to clinical standards suitable for medical decision-making. It is ordered, interpreted, and acted on by a board-certified MD.
Not initially. The first step is testing the person most likely to carry a mutation, usually the relative with the youngest cancer diagnosis. Once a specific mutation is identified, single-site testing for relatives is far less expensive and is almost always covered by insurance. We help coordinate that cascade testing across the family.
The Natera laboratory is HIPAA compliant and does not share identifiable data with third parties without your consent. Federal law (GINA) prohibits employers and health insurers from using genetic test results to discriminate. GINA does not extend to life, disability, or long-term-care insurance, which is something we discuss with you before testing.
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Empower is a physician-ordered hereditary cancer panel, interpreted in line with national genetic-risk guidelines, in a Joint Commission accredited setting. These independent sources are offered for further reading.
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One sample, read by a board-certified physician, can change how you protect your health and your family’s for years to come.
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