NAD+ IV Therapy in Miami: Cost, Protocol, and What to Expect

Medically reviewed by Uri Gedalia, MD, FACS
Chief Medical Officer, TrufaMED Urgent Care & Concierge Medicine
Board-Certified, General Surgery
Last reviewed: June 2026

NAD+ IV therapy has gone from biohacker fringe to mainstream wellness in the last five years. Bryan Johnson uses it, Joe Rogan uses it, and a meaningful subset of Miami's longevity-curious patients now ask about it by name. The question we get most often: is it actually worth $1,000?

This post is a candid clinical walkthrough — what NAD+ is, what the research does and does not support, what the actual protocol looks like at our Surfside clinic, who we recommend it for, and who should probably skip it.

What NAD+ Is

Nicotinamide adenine dinucleotide (NAD+) is a coenzyme that every mitochondrion in your body uses to convert food into ATP — the energy currency of cellular metabolism. NAD+ levels decline with age, and the decline correlates with reduced mitochondrial function, slower DNA repair, and various age-associated metabolic patterns.

The intuition behind NAD+ supplementation: restore the substrate and you restore the downstream machinery. The reality is more nuanced. NAD+ supports many enzymes (sirtuins, PARPs, CD38) and the effect of restoring extracellular levels via IV is not the same as restoring intracellular levels in every tissue.

What The Research Supports — Honestly

Where the evidence is reasonable:

• Subjective energy, mental clarity, and well-being — consistent patient-reported effects in observational data
• Cognitive recovery in patients with post-viral fatigue (post-COVID, post-mononucleosis)
• Adjunct support during withdrawal from alcohol and certain substances (with appropriate physician supervision)
• Sleep quality in some patients with disrupted circadian rhythms

Where the evidence is preliminary:

• Lifespan extension — animal data is interesting; human longevity data is not yet available
• Specific disease prevention — mechanism is plausible but clinical endpoints are not yet established
• Cognitive enhancement in healthy adults — reports are mostly subjective

Where the evidence does not support claims:

• Reversal of established neurodegenerative disease (Alzheimer's, Parkinson's)
• Definitive treatment for chronic conditions
• Replacement for established medical therapy

What's In The TrufaMED NAD+ IV

Our standard NAD+ protocol delivers 500 mg of NAD+ in a 500 ml saline base. The drip rate is slow — this is critical for tolerability.

• Total infusion time: approximately 3 to 4 hours
• Pricing: $1,000 per session
• Includes pre-infusion vitals, slow titration to avoid the well-described ‘NAD flush’, and observation during infusion
• Common add-ons: B-complex, glutathione push at end of infusion, magnesium

We do not run NAD+ at a single fixed flat rate. Patients new to NAD+ start at a slower drip rate and titrate up as tolerated. The slow drip is what differentiates a comfortable infusion from a nauseating one. We have heard from patients who experienced rapid NAD+ infusions elsewhere as ‘the worst hour of my life’; we run slower deliberately.

What To Expect During The Infusion

Most patients tolerate NAD+ infusions well when run slowly. Some sensations are common and benign:

• Mild flushing or warmth in the chest and face
• Tightness or pressure in the chest (not pain)
• Mild nausea, usually resolved by slowing the drip
• Increased awareness or alertness (some patients describe a coffee-like alertness)

If any sensation becomes uncomfortable the RN slows the rate. Adjustments are routine, not failures.

Who Is A Good Candidate

• Adults exploring longevity and cellular health protocols who already have a sane foundation (sleep, training, nutrition, stress management)
• Patients recovering from post-viral fatigue or long COVID with a documented cognitive or energy decline
• Adults in their 40s and beyond who want to incorporate NAD+ into a broader optimization plan with physician oversight
• Patients in substance use recovery, with appropriate medical supervision — NAD+ has reasonable evidence as an adjunct here

Who Should Skip It

• Anyone with active malignancy — the NAD+ / sirtuin axis interacts with cancer biology in ways that are not yet well-defined for clinical use
• Pregnant or breastfeeding patients (insufficient safety data)
• Patients who have not addressed the obvious foundations — if you sleep five hours and drink heavily, NAD+ is not the lever
• Anyone seeking treatment for established neurodegenerative or autoimmune disease as a substitute for evidence-based care

Cadence

There is no universal protocol. Common patterns at our clinic:

• Loading: 3 to 5 sessions over 2 to 3 weeks for first-time patients exploring effects
• Maintenance: monthly or quarterly for adults using NAD+ as part of an ongoing optimization plan
• On-demand: single sessions before or after high-stress events, travel, or post-viral recovery

Most patients notice effects after the first or second session, with cumulative effects after the loading phase. Some patients notice nothing meaningful, which is also a legitimate finding.

Frequently Asked Questions

Is NAD+ IV therapy FDA-approved?

NAD+ is not FDA-approved for any specific clinical indication; use is off-label and considered investigational for most applications. Quality of the NAD+ supplied by your provider matters; we source from a US-licensed compounding pharmacy.

Can I do NAD+ at home as mobile IV?

We do offer NAD+ as mobile IV in select cases, though most patients prefer in-clinic for the 3-4 hour duration and access to physician oversight. Discuss with the booking team.

How does NAD+ IV compare to oral NAD+ precursors (NMN, NR)?

Oral NMN and NR can raise NAD+ levels with daily use, but bioavailability is lower than IV. IV produces a high transient peak; oral produces a steadier rise. They are not mutually exclusive; some patients do both.

Is the $1,000 price typical?

Yes. NAD+ IV therapy in Miami is generally priced $750 to $1,500 per session depending on the dose and provider. Our $1,000 single price covers 500 mg in a slow 3-4 hour infusion with physician oversight.