NAD+ Injections,
Explained

The two terms describe different delivery routes. A NAD+ injection is given just under the skin (subcutaneous, or SubQ) or into muscle (intramuscular, or IM) with a small syringe; doses are lower (roughly 25 to 200 mg) and absorption is gradual. NAD+ IV therapy delivers a larger dose, typically 500 mg, straight into a vein over 2 to 4 hours, reaching full bioavailability and an immediate systemic effect. At TrufaMED the IV drip is the primary therapeutic route, with physician-prescribed SubQ available as maintenance between sessions.

A NAD+ IV drip is the loading dose: a high-concentration infusion that saturates your tissues in one sitting. A SubQ injection is the maintenance dose: a smaller amount you self-administer at home to hold your level steady between drips. Think of the IV as filling the tank and the injection as topping it off. Most physician-supervised plans pair monthly IV infusions with SubQ maintenance rather than relying on either one alone. See our full NAD+ IV page for the drip itself.

SubQ NAD+ can be self-administered at home, but only under physician supervision, with proper training, using pharmaceutical-grade vials, and with a valid prescription. Online vendors that sell NAD+ vials without a physician involved should be avoided, because purity, concentration, and sterility cannot be verified without clinical oversight. At TrufaMED we dispense SubQ maintenance kits and provide hands-on training only after your initial IV session and consultation.

Frequency depends on your goals, your current NAD+ status, and your clinical history. A common starting protocol is 2 to 4 IV sessions in the first month, then monthly maintenance. Patients using SubQ between IV sessions typically inject daily to three times a week at lower doses. There is no single correct schedule. Your physician sets it during your consultation based on your needs and how you respond to the first sessions.

At TrufaMED, NAD+ IV therapy is $999 per session at our Surfside clinic, or $1,250 for mobile delivery to your home, hotel, or office across South Florida. Physician-prescribed SubQ maintenance kits are priced separately at roughly $150 to $300 per supply cycle, depending on dose and duration. Every session includes a physician or clinical review. There are no hidden fees. Confirm current pricing with our team when you book.

A SubQ or IM injection feels like any standard shot: a brief pinch with minimal discomfort. The IV drip is different. As the NAD+ enters your bloodstream you may notice warmth in the face and chest, a mild fluttering sensation, or a feeling of pressure. These sensations depend on the infusion rate and ease when the drip is slowed. Most patients find it manageable, especially after the first session once they know what to expect. Our clinicians adjust your rate in real time.

NAD+ therapy is a targeted intervention, not a universal fix. It is most relevant for high performers facing cognitive fatigue, adults over 40 focused on healthspan, people recovering from post-viral exhaustion, athletes managing recovery load, and patients in supervised addiction-recovery settings. A physician evaluation comes first to confirm it is appropriate and to rule out contraindications. We do not run NAD+ as a walk-up wellness service.

Yes. NAD+ IV is not recommended during pregnancy. Patients with an active cancer diagnosis should defer to their oncologist before starting, since added NAD+ may theoretically support cell proliferation. People with certain cardiac arrhythmias, hemodynamic instability, or significant kidney or liver dysfunction need an individual physician assessment first, and some psychiatric medications can interact. A TrufaMED physician reviews all of this before your first session.

NMN and NR are oral NAD+ precursors: the body converts them into NAD+ after absorption. Their appeal is convenience and cost. Their limits are variable gut absorption, first-pass metabolism, and the ceiling of what you can practically swallow. An injection or IV bypasses all of that and delivers usable NAD+ directly, at a dose oral supplements cannot reach. Many patients use oral precursors daily and add an IV infusion monthly as a tiered strategy.

Yes. NAD+ IV and hyperbaric oxygen are often used together in longevity and performance protocols: HBOT increases oxygen delivery to the mitochondria, and NAD+ supplies the cofactor those mitochondria need to make energy. The pairing is reasonable under physician supervision. NAD+ can also follow standard hydration or vitamin drips on separate days. Stacking two infusions in one session is evaluated case by case. Ask our team about a combined plan.