New · Physician-Administered · Surfside, FL
500 mg IV Next-Gen NAD+ Longevity

Niagen 500 mg IV The NAD+ upgrade.

The next evolution of NAD+ therapy — a 500 mg IV of pharmaceutical-grade Niagen® (nicotinamide riboside) that lifts intracellular NAD+ 20% higher than conventional NAD+ IV, in a session that is 75% shorter. No flushing. No chest pressure. No four-hour drip. $1,200 per session, $3,200 for a package of four.

500 mg sessions only — no reduced-dose tier. Results vary. Niagen IV is a wellness and longevity service, not a treatment for any disease.

Reserve In-Clinic Reserve Mobile
500mg
Per Session
~60min
Full Session
+20%
NAD+ at 3 Hrs
75%
Faster vs NAD+
Quick Answer

What is a Niagen 500 mg IV?

The short answer

Niagen is a patented, pharmaceutical-grade form of nicotinamide riboside chloride (NRCl) — a small vitamin B3 molecule that enters your cells directly and converts into NAD+, the coenzyme every mitochondrion needs to produce energy. At TrufaMED, Niagen is delivered exclusively as a 500 mg IV in our Surfside lounge under physician oversight. Sessions run about sixty minutes — roughly three hours shorter than a comparable NAD+ IV — with a side-effect profile that is, for most patients, simply no side effects at all.

Why The Switch

The numbers patients feel on the drip.

Clinical evaluation of 500 mg Niagen IV versus conventional NAD+ IV shows three endpoints that matter: higher NAD+ uptake, shorter sessions, and a cleaner tolerability profile. These are the reasons our physicians moved Niagen to the top of the longevity menu.

+20%
Higher NAD+ at 3 Hours

Clinical evaluation of 500 mg IV Niagen measured intracellular NAD+ approximately 20% higher at the 3-hour mark versus baseline — the research endpoint most closely tied to the cellular-energy experience patients report.

75%
Faster Than NAD+ IV

A full conventional NAD+ IV takes three to four hours to deliver safely. A 500 mg Niagen IV is complete in roughly one hour — a 75% reduction in chair time without giving up the NAD+ pathway benefit.

0
Attributable Adverse Events

The first clinical study of intravenous nicotinamide riboside (ChromaDex, 500 mg IV) reported no attributable adverse events. In our patient experience, the most common “side effect” of Niagen IV is the absence of any side effects at all.

500 mg IV · One Premium Dose
One dose. No tier below it.

TrufaMED only administers Niagen at 500 mg. We do not offer reduced-strength sessions. Every Niagen IV is drawn from pharmaceutical-grade stock, prepared by a registered nurse, and delivered in our boutique IV lounge — never rushed, never under-dosed.

  • Dose: 500 mg Niagen® (nicotinamide riboside chloride)
  • Route: Intravenous drip only — no IM, no subcutaneous, no take-home
  • Session length: approximately 60 minutes chair time
  • Setting: TrufaMED IV lounge, Surfside flagship
  • Complimentary: red light therapy runs during every in-clinic session
  • Oversight: physician-supervised, RN-administered
The Science

How Niagen becomes NAD+.

Nicotinamide riboside chloride (NRCl) is a patented, pharmaceutical-grade form of vitamin B3 and one of the most direct dietary precursors to nicotinamide adenine dinucleotide (NAD+) — the coenzyme every cell uses to generate ATP, activate sirtuins, and run PARP-mediated DNA repair.

NAD+ levels decline with age. By the 40s, tissue NAD+ concentrations have fallen substantially from their 20-year-old baseline, a shift that correlates with measurable decreases in mitochondrial efficiency, stem-cell function, and cellular stress response.

Direct NAD+ IV therapy works — but it works the hard way. NAD+ itself is a large molecule that struggles to cross cell membranes and is partially catabolized extracellularly. That is why a conventional NAD+ IV runs three to four hours and is often accompanied by flushing, chest pressure, or nausea.

Niagen is fundamentally different. Nicotinamide riboside is small enough to pass through cell walls directly, where your own cellular enzymes (NRK1, NRK2, and NMNAT) convert it to NAD+ in-situ. The pathway is already there — Niagen just provides the substrate. The practical consequences are the three numbers above: higher NAD+ elevation, shorter session, cleaner tolerability.

This is the reason a growing number of longevity clinics have switched from NAD+ IV to Niagen IV as their default NAD+-pathway protocol. It is also the reason TrufaMED now runs Niagen at 500 mg as its flagship longevity IV.

  • Patented B3 molecule — Niagen® is a patented, pharmaceutical-grade form of nicotinamide riboside chloride
  • Small-molecule advantage — NR is significantly smaller than NAD+, enabling direct cellular uptake via nucleoside transporters
  • In-cell conversion — NRK1 and NRK2 kinases phosphorylate NR to NMN; NMNAT enzymes then produce NAD+ inside the cell
  • Mitochondrial fuel — NAD+ is the primary electron carrier in the mitochondrial electron transport chain that generates ATP
  • Sirtuin activation — SIRT1, SIRT3, and SIRT6 — the longevity-associated enzymes — are NAD+-dependent
  • DNA repair cofactor — PARP enzymes consume NAD+ to repair oxidative and genotoxic damage to DNA
  • Measurable endpoint — Clinical evaluation showed ~20% higher NAD+ vs baseline at 3 hours post-infusion
  • Tolerability — No attributable adverse events in initial 500 mg IV Niagen clinical study
Niagen vs NAD+ IV

Side by side, the numbers tell the story.

Both Niagen IV and NAD+ IV elevate cellular NAD+. The path, the session, and the experience are meaningfully different. Here is exactly how they compare.

Factor NAD+ IV Niagen 500 mg IV
Active molecule NAD+ itself — large coenzyme Nicotinamide riboside — small B3 precursor
Cellular uptake Limited membrane permeability; partially catabolized before reaching the cell ✓ Direct entry via nucleoside transporters; in-cell conversion
NAD+ elevation at 3 hrs Baseline reference ✓ ~20% higher than baseline
Typical session length 180–240 minutes ✓ ~60 minutes (75% shorter)
Tolerability Flushing, chest pressure, nausea at standard infusion rates ✓ No attributable adverse events in 500 mg IV evaluation
Patient experience Long, sometimes intense — pacing required ✓ Calm, short, return-to-day friendly
Ideal use case Periodic high-dose cellular reset Monthly to biweekly longevity maintenance
TrufaMED pricing NAD+ IV $999 Niagen 500 mg $1,200 single · $3,200 package of 4

Comparison reflects TrufaMED clinical experience and published Niagen IV evaluations (ChromaDex, 500 mg IV). Individual response varies. “75% faster” is based on standard 240-minute NAD+ IV protocol versus ~60-minute 500 mg Niagen IV session.

Why Patients Choose It

What Niagen 500 mg IV can support.

Niagen is used in longevity medicine to support the downstream physiology of cellular NAD+ — the pathways that underlie energy, repair, and healthy aging. Individual response varies.

Sustained Cellular Energy

NAD+ is the electron shuttle at the center of the mitochondrial electron transport chain. Elevated intracellular NAD+ is the biochemical basis of the energy and stamina patients describe after a Niagen session.

Healthy Aging & Longevity

NAD+ powers sirtuins — the SIRT1/SIRT3/SIRT6 enzymes implicated in cellular longevity signaling. Niagen is a cornerstone of evidence-informed longevity protocols alongside HBOT and periodic lab monitoring.

DNA Repair & Cellular Resilience

PARP enzymes consume NAD+ to repair DNA strand breaks after oxidative and UV damage. Maintaining intracellular NAD+ is a mechanism tied to cellular resilience under environmental and metabolic stress.

Cognitive Clarity & Focus

Neuronal NAD+ status is implicated in mitochondrial bioenergetics for alertness and mental endurance. Executives, founders, and performance-oriented patients commonly incorporate Niagen into weekly or biweekly routines.

Metabolic & Cardiovascular Support

NAD+ participates in over 500 enzymatic reactions, including lipid oxidation and glucose metabolism. Niagen is often paired with physician-supervised metabolic optimization and cardiovascular wellness protocols.

Tissue Repair & Recovery

Stem cell function, tissue regeneration, and inflammation resolution are all NAD+-dependent. Athletes and recovery-focused patients pair Niagen with amino acid IV therapy and HBOT.

Both, On Purpose

We still offer NAD+ IV. Here is why.

Niagen does not replace NAD+ IV — it joins it. The two therapies elevate NAD+ through different mechanisms and serve different clinical moments. Many TrufaMED longevity patients run both on a coordinated schedule, each for the role it does best.

Flagship Protocol

Niagen 500 mg IV

The default NAD+-pathway session. Shorter, cleaner, easier to schedule on a monthly or biweekly cadence. Best for patients building a consistent longevity routine and for first-time NAD+-pathway users who want a gentler introduction.

  • ~60-minute session
  • Direct cell-wall entry; in-cell conversion to NAD+
  • ~20% higher NAD+ at 3 hours vs baseline
  • No attributable adverse events in clinical evaluation
  • $1,200 single · $3,200 package of 4
Legacy Protocol

NAD+ IV

The direct NAD+ molecule delivered intravenously — TrufaMED’s full-dose NAD+ infusion. Remains our choice for patients who specifically want direct NAD+ replenishment, for quarterly cellular-reset sessions, or for concierge protocols that combine both therapies in sequence.

  • Full-session infusion — 90 to 240 minutes
  • Direct NAD+ replenishment in circulation
  • Standard longevity-clinic approach since 2015
  • Flushing, chest pressure possible at faster rates
  • $999 per session

Your physician will recommend the right protocol — or the right rotation of both — based on your longevity goals, lab biomarkers, and session tolerability. Learn more about NAD+ IV therapy or call (305) 537-6396 to speak with our clinical team.

Who It’s For

Who benefits from Niagen 500 mg IV?

Niagen IV is used in a variety of physician-supervised contexts — from high-output professionals to patients building long-term longevity routines. Every candidate is screened for contraindications before their first session.

Longevity-Focused Adults

Patients building a structured healthy-aging routine — typically in their 30s, 40s, and 50s — use Niagen IV on a monthly or biweekly cadence alongside lab monitoring to track biomarkers of metabolic and mitochondrial function over time.

High-Output Executives

Founders, executives, and professionals under sustained cognitive and travel demand cycle Niagen for energy stability and mitochondrial resilience. Our concierge medicine members integrate Niagen into quarterly performance protocols.

Athletes & Recovery

High-volume training depletes NAD+ stores. Niagen IV supports the cellular-repair pathways active during the recovery window, particularly paired with hydration, amino IV therapy, and HBOT.

Patients Already on NAD+

If you already know NAD+ IV, you will feel the difference: shorter sessions, no flushing, no chest pressure, and measurably higher NAD+ uptake per session. Most patients keep quarterly NAD+ IVs as the anchor and build Niagen as the monthly maintenance.

Peri- & Post-Menopausal Patients

Energy metabolism and mitochondrial support are areas of active clinical interest during hormonal transitions. When coordinated with a physician’s overall plan, Niagen IV can be part of a comprehensive energy and resilience strategy.

Post-Illness & High-Travel Recovery

Patients recovering from prolonged illness, intense travel schedules, or extended physical and cognitive demand benefit from targeted NAD+ pathway support. Always under physician assessment to confirm appropriateness.

Transparent Pricing

Single dose. Three ways to own it.

Every Niagen IV at TrufaMED is 500 mg. The only variable is how you want to pay for it — one session at a time, a 4-session package, or as part of a concierge Elite membership that folds Niagen into your ongoing longevity protocol. No reduced doses. No loyalty games. No hidden add-ons.

Single Session
$1,200
per 500 mg IV

The full Niagen experience, no commitment. Ideal for first-timers, travelers stopping through South Florida, or patients testing Niagen against their current NAD+ protocol.

  • 500 mg Niagen IV — full dose
  • Physician intake & clearance
  • RN-administered in our Surfside lounge
  • Complimentary red light therapy
  • Post-session clinical note on file
Book a Single Session
Best Value
Package of 4
$3,200
$800 per session · save $1,600

The protocol most patients land on — four Niagen sessions spaced two to four weeks apart for a full quarterly longevity arc. Lock in the package, save $1,600 off single-session pricing, and never think about rebooking.

  • Four 500 mg Niagen IV sessions
  • Save $1,600 vs single-session pricing
  • Priority scheduling in our IV lounge
  • Complimentary red light at every session
  • Physician-reviewed cadence plan
  • Package credit valid 12 months
Reserve Package of 4
Concierge Elite
Included
with Elite membership

Niagen IV is built into the TrufaMED Elite concierge membership as part of our longevity protocol. Quarterly Niagen, quarterly biomarker labs, HBOT, and full urgent care — designed around a single physician who knows you.

  • Niagen IV included in membership cadence
  • Quarterly longevity biomarker labs
  • Direct access to your physician
  • Coordinated NAD+ & HBOT protocols
  • Full urgent care covered in membership
Explore Concierge

Niagen IV is a self-pay wellness service; not covered by insurance. TrufaMED accepts major credit cards, FSA, and HSA cards. Package credits are non-transferable and valid for twelve months from purchase.

What to Expect

Your Niagen IV session.

Every Niagen IV at TrufaMED follows the same rhythm — physician-reviewed, nurse-administered, start to finish in about an hour. Here is exactly what you experience when you walk in.

Step 1: Physician Intake

First-time patients complete a brief physician intake. We review your medical history, medications, and goals to confirm Niagen 500 mg IV is the right fit. Follow-up sessions require a shorter RN check-in only.

Step 2: IV Placement

A registered nurse places a small-gauge IV catheter — typically at the inner elbow or forearm. Most patients feel a brief pinch. Placement takes under ninety seconds.

Step 3: Infusion

Your 500 mg Niagen IV infuses over approximately sixty minutes in our IV lounge with complimentary red light therapy running in parallel. Most patients work, read, or rest. No loading dose. No pacing pauses.

Step 4: Discharge

Your IV is removed, a brief post-infusion check confirms you feel well, and your clinical record is updated. Most patients leave immediately and return to normal activity. Your next session is scheduled on your physician-recommended cadence.

Our Medical Team

Physician-led. Always.

Niagen IV at TrufaMED is dispensed only under active physician standing orders reviewed by our Medical Director. Your session is never unsupervised and never administered by anyone outside our clinical team.

Dr. Uri Gedalia MD
Board-Certified General Surgeon · Chief Medical Officer

Dr. Gedalia leads TrufaMED’s longevity and IV therapy programs with a focus on evidence-based formulations. His surgical background informs his understanding of mitochondrial physiology in perioperative and high-demand states. He oversees Niagen protocol development, pharmacy sourcing, and clinical oversight.

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Dr. Shane D. Naidoo MD
Board-Certified Emergency Medicine · Medical Director

Dr. Naidoo brings emergency medicine expertise to TrufaMED’s clinical safety protocols. His background in acute resuscitation and IV fluid management ensures that Niagen dispensing, adverse-event protocols, and standing orders are grounded in hospital-grade clinical standards.

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Safety & Screening

Precautions & contraindications.

Niagen IV is administered only after a physician-supervised intake. The following are the standard precautions every patient is screened against before their first session.

Avoid

Do not take Niagen IV if you:

  • Have a current or prior history of cancer (NAD+ pathway interactions with cellular proliferation signaling require physician clearance)
  • Are pregnant or breastfeeding — Niagen IV has not been evaluated in these populations
  • Have active or uncontrolled rheumatoid arthritis — physician review required
  • Have a known hypersensitivity to nicotinamide riboside or any component of the formulation
Use With Caution

Talk to your physician if you:

  • Are taking diabetes medications — Niagen may influence glucose metabolism; monitor blood sugar
  • Are on blood thinners (warfarin, DOACs, antiplatelets) — additional site care may apply
  • Have chronic kidney or liver disease — dosing is individualized based on organ function
  • Are taking other NAD+ precursors or high-dose B3 supplements — your physician will advise on stacking and timing

This list is not exhaustive. A complete medical history and medication list are reviewed prior to every first-time session. Niagen is a compounded injectable drug and is not FDA-approved as a therapeutic. Adverse events are reported to fda.gov/medwatch. For medical emergencies, call 911.

FAQ

Frequently asked questions.

What is a Niagen 500 mg IV?
Niagen is a patented, pharmaceutical-grade form of nicotinamide riboside chloride — a vitamin B3 molecule that acts as a direct precursor to NAD+. At TrufaMED, Niagen is administered exclusively as a 500 mg IV over approximately sixty minutes, delivered by a registered nurse in our Surfside IV lounge under physician oversight.
How is Niagen IV different from NAD+ IV?
NAD+ IV delivers the NAD+ molecule itself — a large coenzyme that must be infused slowly over three to four hours, often with flushing or chest pressure. Niagen IV delivers nicotinamide riboside, a smaller B3 molecule that passes directly through cell walls and is converted to NAD+ inside the cell. Clinical evaluation of 500 mg IV Niagen measured approximately 20% higher NAD+ at 3 hours post-infusion versus baseline, with no attributable adverse events. The session runs about 60 minutes — roughly 75% shorter than conventional NAD+ IV.
Why only 500 mg? Can I get a lower dose?
No. TrufaMED administers Niagen exclusively at 500 mg. We do not offer a reduced-dose tier. Clinical evaluation supporting Niagen IV used the 500 mg IV dose, and we believe patients pursuing a premium longevity protocol deserve the full clinical experience, not a partial one. If 500 mg Niagen is not the right fit for you, your physician may recommend our NAD+ IV program instead.
How long does a Niagen IV session take?
A 500 mg Niagen IV session runs approximately sixty minutes including setup. That is about 75% shorter than a standard NAD+ IV, which typically requires 180 to 240 minutes. Most patients work, read, or simply rest during the infusion. Complimentary red light therapy runs in parallel.
What are the side effects of Niagen IV?
Clinical evaluation of 500 mg IV Niagen reported no attributable adverse events. In our patient experience, the typical Niagen IV experience involves no flushing, no chest pressure, and no nausea — the three discomforts most commonly reported on conventional NAD+ IV. Occasional mild warmth at the infusion site may occur. Niagen IV is not appropriate for patients with current or prior cancer, pregnancy, breastfeeding, active rheumatoid arthritis, or known hypersensitivity, all of which are screened during intake.
How often can I get Niagen IV?
Typical longevity-maintenance cadence is monthly to biweekly — most TrufaMED patients settle into a schedule of one to two Niagen IV sessions per month. Your physician will recommend a cadence after your intake based on your goals, response, and biomarker monitoring. Our Package of 4 is designed around a quarterly longevity arc, typically four sessions spaced two to four weeks apart.
How much does Niagen IV cost at TrufaMED?
A single 500 mg Niagen IV session is $1,200. Our Package of 4 is $3,200 — $800 per session, a savings of $1,600 versus single-session pricing. Niagen IV is also included as part of the TrufaMED Concierge Elite membership. Niagen IV is a self-pay wellness service and is not covered by insurance. We accept major credit cards, FSA, and HSA.
Do you still offer NAD+ IV?
Yes. NAD+ IV remains part of the TrufaMED longevity menu at $999 per session. Niagen IV is our new flagship NAD+-pathway protocol, but NAD+ IV remains available for patients who specifically want direct NAD+ replenishment or who prefer to combine both therapies in sequence. Your physician will help design the right protocol for your goals.
Is Niagen FDA-approved?
Niagen injectable is a compounded drug prepared by a licensed US compounding pharmacy and is not an FDA-approved therapeutic. It is dispensed for office use only under active physician standing order. Nicotinamide riboside as a raw ingredient is classified as a generally recognized safe dietary form of vitamin B3.
Is Niagen IV available at home, at my hotel, or by mobile?
Yes. Niagen 500 mg IV is available both in our Surfside IV lounge and as a mobile IV visit throughout South Florida — Miami Beach, Bal Harbour, Sunny Isles Beach, Bay Harbor Islands, Aventura, Brickell, and surrounding areas. Book in-clinic at trufamed.janeapp.com, or book mobile Niagen via the mobile Niagen booking link. Mobile Niagen is a registered-nurse home or hotel visit; our mobile standard is a 2.5-hour window with a priority-fee option for same-day. See our mobile IV menu for the broader selection.
When will I feel the effects?
Most patients describe a clean, steady lift in energy and clarity during the infusion itself and for hours afterward. The biochemical endpoint most cited in clinical evaluation — approximately 20% higher NAD+ versus baseline — peaks near the three-hour mark post-infusion. Cumulative longevity benefit develops over a consistent monthly or biweekly cadence, which is why most patients elect the Package of 4.
Can Niagen IV be combined with other services at TrufaMED?
Yes. Niagen IV combines well with HBOT, amino acid IV therapy, glutathione, and physician-directed peptide protocols. Your physician will sequence these for maximum synergy. Many concierge patients pair a Niagen IV with an HBOT session in the same visit.
What makes TrufaMED’s Niagen IV different?
TrufaMED is Joint Commission accredited, the only urgent care in Florida with this distinction. Niagen IV is dispensed only under active standing orders from our board-certified physicians — a General Surgeon and an Emergency Medicine physician with hospital-grade IV experience. Our Niagen is sourced from a licensed US compounding pharmacy, never a supplement manufacturer. Every patient receives a physician intake before their first session. This is clinical longevity medicine, not a spa amenity.
Visit Us

Niagen IV at Surfside.

The TrufaMED Niagen IV program is delivered in our boutique IV lounge at 9445 Harding Ave, Surfside, FL 33154 — two minutes from Bal Harbour Shops, fifteen minutes from South Beach — and as mobile Niagen IV visits throughout South Florida. Choose the setting that fits your schedule.

TrufaMED Urgent Care & Concierge Medicine

Address: 9445 Harding Ave, Surfside, FL 33154
Phone: (305) 537-6396
WhatsApp: +1 (305) 842-9801

Open 7 Days · Hours
TrufaMED hours of operation
Monday – Friday9:00 AM – 9:00 PM
Saturday11:00 AM – 11:00 PM
Sunday12:00 PM – 8:00 PM

Niagen IV is available in our Surfside flagship and as a mobile IV visit across Miami Beach, Bal Harbour, Sunny Isles Beach, Bay Harbor Islands, Aventura, Brickell, and surrounding South Florida communities. Concierge medicine members schedule Niagen as part of their membership protocol.

Book Today

Aging never looked this good.

A 500 mg Niagen IV. About an hour. No flushing. No chest pressure. Just the NAD+ pathway, the short way around. Available in-clinic at our Surfside lounge or as a mobile visit across South Florida.

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Medical Disclaimer: The content on this page is provided for general informational and educational purposes only. It does not constitute medical advice, diagnosis, or treatment. Niagen® (nicotinamide riboside) as dispensed at TrufaMED is a compounded injectable drug prepared by a licensed US compounding pharmacy for office use only, and is not FDA-approved as a therapeutic. Niagen IV is a wellness and longevity service; individual results vary and are not guaranteed. It is not appropriate for all individuals — contraindications include current or prior cancer, pregnancy, breastfeeding, active rheumatoid arthritis, and others identified during clinical screening. Clinical data cited on this page (approximately 20% higher NAD+ at 3 hours; no attributable adverse events) reflect published evaluation of 500 mg IV Niagen; individual response varies and is not guaranteed. Always consult a qualified healthcare provider before beginning any IV therapy. TrufaMED’s protocols are physician-overseen and administered by registered nurses in a Joint Commission-accredited facility. Adverse events are reported to fda.gov/medwatch. For medical emergencies, call 911 immediately.