NAD+ IV Therapy Miami.
Physician-Formulated · Joint Commission Accredited · In-Clinic or Mobile
Nicotinamide adenine dinucleotide (NAD+) IV infusion — the cellular coenzyme that powers mitochondrial energy production, DNA repair, and sirtuin activation. Delivered by a physician-directed team in Surfside, or mobile to Miami Beach, Bal Harbour, and South Florida.
Starting at $999 in-clinic. $1,250 mobile. Slow infusion 2–4 hours with clinical monitoring. Red light therapy included free with every in-clinic session.
What does NAD+ IV therapy do?
NAD+ IV therapy delivers nicotinamide adenine dinucleotide directly into your bloodstream, bypassing gut absorption. At TrufaMED, physician-supervised NAD+ infusions support mitochondrial energy production, activate sirtuins involved in DNA repair, and may assist cognitive clarity and metabolic resilience. Sessions run 2–4 hours and are monitored by our clinical team throughout.
What is NAD+?
Nicotinamide adenine dinucleotide (NAD+) is a coenzyme found in every living cell. It is not a hormone, peptide, or pharmaceutical drug — it is a naturally occurring molecule that your body synthesizes and depends on for basic cellular function.
NAD+ operates as an electron carrier in the mitochondria, shuttling electrons through the electron transport chain to produce ATP — the energy currency that powers cellular activity. Without adequate NAD+, mitochondrial output drops, cellular repair slows, and metabolic efficiency declines.
Mitochondrial Function
Inside the mitochondria, NAD+ accepts electrons from nutrient metabolism and delivers them to the electron transport chain. This process — oxidative phosphorylation — is responsible for roughly 90% of the ATP your cells produce. When NAD+ levels are low, this chain becomes less efficient, contributing to fatigue, cognitive slowness, and reduced physical recovery capacity.
DNA Repair and PARP Enzymes
NAD+ is the substrate for PARP (poly ADP-ribose polymerase) enzymes, which detect and repair DNA strand breaks. Adequate NAD+ supports genomic integrity. When NAD+ is depleted — as occurs with aging or metabolic stress — DNA damage accumulates more rapidly than it can be repaired.
Sirtuin Activation
Sirtuins (SIRT1–SIRT7) are a family of NAD+-dependent enzymes involved in gene expression regulation, inflammation control, and cellular stress response. Research suggests sirtuins play a meaningful role in healthspan. Sirtuins require NAD+ as a cofactor — they cannot function without it. Restoring NAD+ levels supports sirtuin activity.
Why IV Delivery?
Oral NAD+ precursors (NMN, NR) must be converted through enzymatic pathways before becoming usable NAD+. Absorption and conversion efficiency vary significantly between individuals. IV NAD+ delivers the coenzyme directly into circulation at predictable concentrations, allowing clinical dosing precision that oral supplements cannot provide.
- Electron carrier in oxidative phosphorylation
- Substrate for PARP DNA repair enzymes
- Required cofactor for sirtuin (SIRT1–SIRT7) enzymes
- Involved in circadian rhythm regulation via NAMPT pathway
- Supports cellular NAD+/NADH redox balance
- Precursor to NADP+ (involved in antioxidant glutathione recycling)
- Required for CD38 and SARM1 enzyme activity
- Declining measurably from the third decade of life onward
Why NAD+ levels decline.
Research published in peer-reviewed journals — including work from the Sinclair Lab at Harvard Medical School and the Imai Lab at Washington University — has documented a consistent decline in tissue NAD+ levels beginning in the third decade of life and accelerating with age and metabolic stress.
NAD+ biosynthesis declines with age. CD38 — an NAD+-consuming enzyme — increases with aging, accelerating depletion. By the sixth decade, NAD+ levels may be 50% lower than in young adulthood.
Alcohol metabolism consumes NAD+ at an accelerated rate. Heavy or chronic alcohol use significantly depletes hepatic NAD+ stores, impairing both energy metabolism and DNA repair capacity.
Systemic inflammation activates PARP enzymes and CD38, both of which consume NAD+. Inflammatory conditions create a cycle where NAD+ depletion reduces the body’s ability to resolve inflammation.
Obesity, insulin resistance, and poor metabolic health are associated with lower NAD+ availability. Caloric excess can shift the NAD+/NADH ratio unfavorably, reducing the pool of oxidized NAD+ available for energy metabolism.
TrufaMED’s NAD+ IV Protocol.
Every NAD+ infusion at TrufaMED is ordered by a physician and administered by our registered nursing team under physician oversight. We do not rush NAD+ delivery — the slow infusion rate is medically necessary to minimize the dose-dependent side effects that accompany rapid administration.
Brief clinical assessment to confirm candidacy, review medications and contraindications, and determine appropriate dose. First-time patients receive a thorough intake. We do not administer NAD+ without physician review.
Our RN team places a peripheral IV and prepares the NAD+ formulation. Standard dose is $999 in-clinic. Higher-concentration sessions are available for established patients. All formulations are pharmacy-grade.
NAD+ must infuse slowly. Rapid administration causes chest discomfort, nausea, flushing, and muscle cramping. Our team titrates the drip rate to your individual tolerance, pausing or slowing as needed. You remain monitored throughout.
Every in-clinic NAD+ session includes complimentary red light therapy (photobiomodulation). Clinical-grade 630–850nm panels support mitochondrial ATP production — a mechanistic complement to NAD+ infusion.
Evidence-Based Benefits.
Research on NAD+ therapy is evolving rapidly. We present what the current evidence supports — and are explicit about where it remains preliminary. We do not overclaim. Our role is to help you make an informed decision with your physician.
Well-supported by preclinical and early clinical research. NAD+ is a required substrate for mitochondrial electron transport. Restoring declining NAD+ levels supports ATP production efficiency. Most patients report improved energy within 24–48 hours of infusion.
Preliminary human studies and substantial animal research suggest NAD+ repletion may support neuronal energy metabolism and neuroprotection. Some patients report clearer thinking and reduced mental fatigue. Robust human RCT data is still limited — we classify this as emerging.
Sirtuin activation downstream of NAD+ repletion may influence senescent cell signaling and extracellular matrix maintenance. Early clinical interest exists around NAD+ and photoaging, though large-scale skin trials in humans are limited. Red light therapy included free with every in-clinic session adds a documented dermal collagen benefit.
NAD+ supports muscle cell energy metabolism and may assist recovery from physical exertion or surgical procedures by restoring mitochondrial function in recovering tissue. Physician consultation is required for post-surgical applications to confirm appropriate timing.
The most clinically documented application of IV NAD+. Published case series and clinical protocols document NAD+ infusion as a supportive adjunct during alcohol detoxification and opioid cessation — helping replenish depleted NAD+ stores and supporting neurological recovery. This application requires physician oversight and is not a standalone addiction treatment.
Emerging research on post-COVID fatigue syndrome and ME/CFS identifies mitochondrial dysfunction and NAD+ depletion as potential contributing factors. Early case reports suggest some patients experience fatigue improvement with NAD+ repletion. Formal clinical trial evidence in this population remains limited.
What NAD+ IV Is Not.
Responsible medicine requires honesty. At TrufaMED, our physicians are trained in evidence-based practice. We will not overstate what the current science supports. Before booking, understand what NAD+ IV therapy is not.
Not FDA-approved as an anti-aging therapy. NAD+ IV infusion is not FDA-approved for any specific indication related to aging reversal, longevity, or disease treatment. It is administered as a wellness infusion under physician supervision.
Not a cure-all. No single infusion resolves chronic illness, reverses years of cellular damage, or replaces the foundations of metabolic health — sleep, nutrition, exercise, and stress management. NAD+ IV is a supportive tool, not a replacement for comprehensive care.
Not painless. NAD+ infusion is known to cause transient discomfort including warmth, chest fluttering, a sense of pressure, mild nausea, and muscle cramping. These are dose-dependent and rate-dependent. Our team manages them by adjusting infusion speed — but you should know they are part of the experience, particularly on your first session.
Not a quick drip. Unlike hydration IVs that run 30–60 minutes, NAD+ requires 2–4 hours of monitored infusion. Plan accordingly.
Not appropriate for everyone. Contraindications apply. See the “Who Should Not Do NAD+ IV” section below. A physician intake is required before every infusion.
Not a substitute for psychiatric care. While NAD+ has been studied as a supportive adjunct in addiction medicine, it is not a substitute for licensed mental health treatment, psychiatric medication, or addiction counseling.
Not interchangeable with oral NMN or NR. NAD+ precursors taken orally must be converted enzymatically. IV NAD+ is a different delivery modality with different pharmacokinetics. The two are not equivalent.
Who Benefits Most.
NAD+ IV therapy is not for everyone — and that is the point. Our physicians help you evaluate whether your clinical picture makes you a strong candidate. The patients who benefit most typically share one or more of the following profiles.
Executives, entrepreneurs, and professionals experiencing cognitive fatigue, declining recovery speed, or reduced metabolic efficiency. NAD+ decline is measurable by the mid-30s and accelerates through the 40s and 50s.
Individuals actively optimizing healthspan who understand the evidence landscape around NAD+ and want IV delivery for pharmacokinetic precision that oral precursors cannot match.
Patients with unexplained persistent fatigue, post-COVID syndrome, or conditions associated with mitochondrial dysfunction. Physician evaluation required to rule out treatable underlying causes first.
Patients in alcohol or opioid recovery programs, under physician oversight, where NAD+ IV has documented supportive clinical use. Must be coordinated with your treating addiction medicine team.
Competitive athletes during deload weeks, off-season recovery phases, or post-competition recovery seeking to support mitochondrial repletion. Works well in combination with our HBOT protocols.
TrufaMED Elite concierge members receive NAD+ IV as part of their comprehensive longevity protocol, coordinated with their primary physician relationship and ongoing health optimization plan.
Who Should Not Do NAD+.
Our physicians review every patient before infusion. The following groups should not receive NAD+ IV without explicit physician clearance, and in some cases are not candidates at all.
Pregnancy. NAD+ IV has not been studied in pregnancy. We do not administer it to pregnant patients.
Active cancer treatment. Patients currently undergoing chemotherapy or radiation therapy should not receive NAD+ IV without explicit clearance from their oncologist. NAD+ supports DNA repair pathways — including in rapidly dividing cells — and the interaction with active cancer protocols is not well characterized.
Certain psychiatric medications. Some antidepressants, antipsychotics, and mood stabilizers interact with serotonin pathways that NAD+ metabolism touches. Our physicians review your medication list carefully before approving any NAD+ infusion.
Severe liver disease. NAD+ metabolism is hepatic. Patients with decompensated cirrhosis or acute hepatic failure require careful evaluation before proceeding.
Uncontrolled hypertension. The cardiovascular sensations associated with rapid NAD+ infusion can be concerning in patients with poorly controlled blood pressure. Stability is required before we proceed.
What to Expect at TrufaMED.
We want you to arrive informed. NAD+ is unlike a standard hydration or vitamin IV — the session is longer, the experience is more intense, and the monitoring more active. Here is exactly what to expect.
Before Your Session
Eat a meal 1–2 hours prior. Coming in on an empty stomach significantly worsens infusion-related nausea and discomfort. A light but substantial meal — protein, healthy fats, complex carbohydrates — helps buffer the sensations.
Hydrate well beforehand. IV access is easier in well-hydrated patients, and overall session tolerance is better when you arrive hydrated.
Bring something to do. Your session will run 2–4 hours. Patients bring laptops, books, headphones. Our infusion chairs are comfortable. You are welcome to work, rest, or watch something during the session.
Avoid alcohol for 24 hours prior. Alcohol depletes NAD+ and compromises liver metabolism of the coenzyme.
During the Infusion
Our RN will place a peripheral IV and begin the drip at a low initial rate, titrating upward based on your tolerance. You will be monitored throughout the session. Expect:
- Warmth in the chest or face — common and transient
- Chest fluttering or palpitation sensation — dose-dependent, typically brief
- Mild nausea — managed by slowing the drip rate
- Muscle cramping or tightness — responds quickly to rate reduction
- General sense of restlessness or unease — resolves as your body adapts
If any sensation is significant, tell your nurse. The rate will be adjusted immediately. All of these effects are reversible and resolve when the infusion slows or stops.
After Your Session
Most patients are able to drive home without difficulty, though some report a mild post-session fatigue during the first session. For your first infusion, consider having someone drive you. You may resume normal activities the same day. Alcohol should be avoided for 24 hours post-infusion.
Every in-clinic NAD+ session at TrufaMED includes complimentary red light therapy. Clinical-grade 630–850nm photobiomodulation panels are positioned during your infusion. Red light therapy has documented effects on mitochondrial cytochrome c oxidase activity — mechanistically complementary to NAD+’s role in the electron transport chain. No additional charge.
- Duration: 2–4 hours (first session may run longer)
- Monitoring: continuous by RN throughout
- Access: private infusion suite, not a shared clinic bay
- Parking: complimentary on-site
- Hours: Mon–Fri 9 AM–9 PM | Sat 11 AM–11 PM | Sun 12–8 PM
- Address: 9445 Harding Ave, Surfside FL 33154
NAD+ IV Therapy Pricing.
Transparent pricing. No surprise fees. No upselling during your infusion. Red light therapy is always included free with in-clinic sessions.
- Physician-supervised infusion
- Registered nurse administration
- 2–4 hour slow infusion
- Red light therapy included free
- Private infusion suite
- Physician intake review
- NAD+ included in monthly allotment
- Access to all 17 IV formulas
- Mobile delivery available
- Red light therapy every session
- Priority physician scheduling
- 3-month minimum term
- Delivered to your home or hotel
- Physician-supervised remotely
- RN administers on-site
- Miami Beach, Bal Harbour, Aventura
- Advance booking required
- Not eligible for red light therapy
NAD+ IV is not typically covered by health insurance. HSA/FSA may apply — contact us to confirm. Payment accepted in full at time of service. No payment plans for single sessions.
Physician-Led Every Session.
Every NAD+ infusion at TrufaMED is ordered by a board-certified physician. This is not a wellness spa. It is a Joint Commission-accredited medical facility where physicians review every patient before infusion and our RN team monitors you throughout.
Dr. Gedalia founded TrufaMED with a mandate for physician-led, evidence-grounded care in South Florida. Board-certified in General Surgery, he oversees clinical protocols including NAD+ infusion standards, contraindication review, and the integration of IV therapy with concierge medicine programs. Under his leadership, TrufaMED became Florida’s only Joint Commission-accredited urgent care — one of eight in the nation.
Dr. Naidoo serves as Medical Director, overseeing day-to-day clinical operations and quality standards at TrufaMED. His board certification in Emergency Medicine brings acute clinical judgment to infusion monitoring protocols — ensuring that the cardiovascular sensations associated with NAD+ infusion are managed with the same rigor applied to acute care. He reviews complex patient intakes personally.
In-Clinic Surfside. Mobile South Florida.
9445 Harding Ave, Surfside, FL 33154
3 minutes from Bal Harbour Shops
10 minutes from Miami Beach
15 minutes from Aventura Mall
Hours:
Monday – Friday: 9 AM – 9 PM
Saturday: 11 AM – 11 PM
Sunday: 12 PM – 8 PM
Phone: (305) 537-6396
WhatsApp: +1 (305) 842-9801
Mobile NAD+ Service Area:
Miami Beach · Bal Harbour · Bay Harbor Islands · Surfside · Sunny Isles Beach · Aventura · Brickell
Common Questions Answered.
How long do the effects of NAD+ IV last?
How often should I get NAD+ IV therapy?
What are the side effects of NAD+ IV therapy?
Why does my chest feel fluttery or uncomfortable during the infusion?
Can I combine NAD+ IV with other TrufaMED services?
Should I fast before my NAD+ IV session?
Can I drive home after a NAD+ IV session?
Is there an age minimum for NAD+ IV therapy at TrufaMED?
Do I need to be a TrufaMED concierge member to get NAD+ IV?
What is nicotinamide adenine dinucleotide and how is it different from NMN or NR supplements?
Does NAD+ IV therapy require a prescription?
Is NAD+ IV covered by insurance or HSA/FSA?
Ready to restore cellular energy?
Physician-supervised NAD+ IV in Surfside — or mobile to your location across South Florida. Book your session or call our team for a clinical intake consultation.
